Tramadol is a very potent synthetic analgesic pain killer. Researchers are unaware of the mechanism of this drug but it is similar to morphine. Similar to morphine, the medication ties to receptors in brain (opioid or narcotic receptors), which are important for sending the sensation of discomfort and pain from all over the body to brain. However, like other narcotics prescribed to heal pain, patients consuming Tramadol might abuse the drug and get addicted to it. It must be noted that this medicine is not a nonsteroidal anti-inflammatory product, thus it does not involve the increased danger of internal bleeding and stomach ulcers, which can occur with nonsteroidal anti-inflammatory medications.
Deaths due to overdose of Tramadol pill have increased to a great extent over the last two decades. Researchers at the U.S. Centers for Disease Control and Prevention (CDC) have found that the proportion of overdose deaths resulting from synthetic opioids like Tramadol have in fact increased from 10 percent in 2011 to 20 percent in 2016. Because many prescribers consider this medicine as a safe opioid than something more potent like morphine, people often disregard drug interaction warnings or dosage instructions. Those who have been abusing Tramadol build dependence over time. These people deliberately increase their doses in an unsafe manner so that they could continue to attain the high.
Signs and Symptoms of Overdose
Opioids work by tying to particular receptors in the mind and hindering the pain signals. They might also affect parts of central nervous system responsible for regulating breathing and reward responses. Taking too much could cause serious and even life-threatening adverse effects. However, Tramadol’s overall effect on archetypical opioid receptor is weak, when compared to other more distinctive opioids. But, the medicine also wields its analgesic effects with additional actions on serotonin and norepinephrine neurotransmitter.
Causes of Overdose
One of the major danger factors for overdose is drug dependence. Although, normal Tramadol dose has demonstrated to have a low potential for dependence and abuse than more strong opioids, such as hydrocodone or codeine, its abuse and misuse rate has in fact been escalating. In the year 2013, about 3.3 million individuals used this medication for non-medical purposes, up from 2.8 million in 2012, according to a new report by National Survey on Drug Use and Health (NSDUH). NSDUH has stated that few demographic factors may play a role in -+overdose. The majority of individuals, who abused this drug, were above the age of 25.
On the other hand, Drug Enforcement Administration in the U.S. has said that Tramadol is likely to be misused by people, who are health professionals, are chronic distress patients, or are already suffering from narcotic addiction. Men are more susceptible to overdose, especially on prescription pain relievers though overdose rates in females have been increasing rapidly in few recent years.
Individuals who have clambered with substance addiction may be more vulnerable to develop dependence on opioids, thus putting them at an increased risk of an overdose. Hence, for better therapeutic outcome, buy Tramadol online after consulting with GP, and take doses properly on time.